Yi Miao

This study identifies teneurins as SPARCL1 receptors and shows that SPARCL1 enhances synapse formation by binding to teneurins via its follistatin-like domain and activating synapse formation via its Ca2+-binding domain.

This study uses single-molecule tracking to show that Lrp6 and Ror2 co-assemble into hybrid Wnt signalosomes dynamically.

This paper identifies 4456dh, a small molecule inhibitor of trehalose-6-phosphate synthase, which disrupts fungal thermal tolerance and virulence.

The paper identifies two lineage-committed progenitors in the developing brain that generate forebrain/midbrain and hindbrain regions, and demonstrates their distinct chromatin landscapes and differentiation potential.

This study identifies how TGF-β1 modulates cell fate in human ES cell-derived foregut endoderm by inhibiting multiple signaling pathways, promoting pancreas fate over liver.

The paper describes engineered surrogate R-spondins that enhance Wnt signaling in specific cell types by bypassing natural receptor interactions.