David Sprinzak

This study shows that mechanical stress influences age-related changes in vestibular hair cell differentiation and regeneration through Notch signaling.

The paper shows that morphological differences influence Notch-mediated lateral inhibition, biasing cells toward signal-sending or receiving roles during neuroblast selection.

The paper identifies a rare subpopulation of cochlear supporting cells that transdifferentiate into hair cells upon Notch inhibition, revealing epigenetic and transcriptional changes associated with this process.

The paper introduces a model linking chromatin and enhancer states to transcriptional bursting dynamics, using the Monod-Wyman-Changeux framework to predict bursting behavior in C. elegans.

The paper shows NEURL proteins activate specific Notch ligands in mammals, unlike MIB1, which may explain their limited developmental role.

This study investigates how the intracellular domain of Fat4 regulates the turnover and dynamics of Fat4/Dchs1 planar polarity complexes using live imaging.

This study identifies the structural requirements of MIB1 for ubiquitin transfer in Notch signaling, showing that RING3 is essential for catalytic activity and dimerization.

This study compares endogenous and synthetic Notch systems to understand why synthetic systems do not require ligand ICD for activation.

The paper investigates the role of cis-inhibition in Notch signaling during sensory organ precursor selection in Drosophila, showing it suppresses basal Notch activity to enable single-cell fate specification.

This study identifies a mechano-signaling feedback mechanism that drives precise inner hair cell patterning in the organ of Corti through coordinated cellular movements and adhesion.

The paper shows that enhancers with SPS sites are more resistant to repression by Hairless co-repressor compared to those with CSL sites.

The paper shows neural stem cells use local feedback mechanisms with delays to coordinate their division and maintain homeostasis in the adult brain.

This study shows that shear forces and local repulsion drive the formation of the checkerboard pattern of hair cells in the mammalian inner ear.

The paper shows that an enhancer with specific binding sites can induce Notch haploinsufficiency phenotypes in Drosophila with wild-type Notch gene dose by promoting rapid Notch turnover through a bind and discard mechanism.

The paper shows that Dll4 inhibits cell recruitment into aortic clusters, reducing hematopoietic stem cell formation.

This study shows that Notch dimerization is critical for intestinal homeostasis and immune responses, with mite infestation worsening related phenotypes and triggering lymphoma in mutant mice.