Alejandro De Los Angeles

This study shows that a low nucleus-to-cytoplasmic ratio in haploid embryonic cells leads to cytokinesis failure, genome instability, and reduced development.

The paper questions the TNT method for iPSC generation by showing persistent Sendai virus expression in hiPSCs, altering reprogramming factor levels and ratios.

The paper uses long-read sequencing to identify novel isoforms and splicing regulators during neuronal differentiation in human neuroblastoma cells.