Peter M.K. Westcott

This study shows that a microbiome-dependent mechanism increases MHC-II expression in colon cancer cells, enhancing immunotherapy response and limiting metastasis.

This study shows that neutrophil extracellular traps (NETs) drive tumor necrosis and metastasis in colorectal cancer, and inhibiting NET formation reduces necrosis and improves chemotherapy outcomes.

This study identifies small molecule inhibitors of TOX protein that reverse T cell exhaustion and show cytotoxicity in T-ALL.

This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.