Elif Ozcelik

A Single-Cell Atlas Reveals Cancer Cell Plasticity and Stromal-Immune Remodeling in Uterine Carcinosarcoma Across Diverse Ancestries

This paper constructs a single-cell atlas of uterine carcinosarcoma across diverse ancestries, revealing cancer cell plasticity and stromal-immune remodeling in primary and metastatic tumors.

Microbial induction of MHC-II expression in colon cancer cells overcomes immunotherapy resistance and limits metastasis

This study shows that a microbiome-dependent mechanism increases MHC-II expression in colon cancer cells, enhancing immunotherapy response and limiting metastasis.

Diverse high-fat diets drive multi-omic reprogramming that persists after dietary reversal

The paper investigates how different high-fat diets affect host and microbiome multi-omic states over time and shows that some changes persist even after returning to a control diet.

Pancreatic cancer-associated organ dysfunction promotes muscle autophagy and contributes to peripheral tissue wasting

This study shows pancreatic cancer disrupts normal pancreatic function, leading to systemic nutrient depletion and muscle wasting, with autophagy in muscle playing a key role in nutrient redistribution to support tumor growth.

The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs

SAHA creates a multimodal, subcellular-resolution reference atlas of healthy human tissues, revealing spatial organization and disease-associated disruptions across multiple organ systems.