Author

Xinyuan Zhang

St Thomas' HospitalORCID 0000-0001-9472-9641Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Alessia MongelliiD· 1 shared Andrea AlimontiiD· 1 shared Aurélien ThomasiD· 1 shared BenoÃ®t Pugin· 1 shared Cristina MenniiD· 1 shared Florentin ConstanciasiD· 1 shared Francesco PaneniiD· 1 shared Frank RuschitzkaiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Alessia MongelliORCID

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1 paper

Recent·Most cited

Gut Microbiota Production of Phenylacetate Programs Vascular Niche Senescence and Drives Atherosclerosis

Khatereh Shabanian, Florentin Constancias, BenoÃ®t Pugin, Taraneh Shabanian, Aurélien Thomas, Sylvain Le Gludic, Marianne Rebecca Spalinger, Alessia Mongelli, Cristina Menni, Xinyuan Zhang, Lorenzo Da Dalt, Manuel Colucci, Héctor Rodríguez Cetina Biefer, Omer Dzemali, Matthias Hermann, , Seyed Soheil Saeedi Saravi

This study identifies phenylacetate (PAA), a gut microbiota metabolite, as a driver of vascular niche senescence and atherosclerosis in mice through IL-6-Notch1 signaling.

bioRxiv · Mar 2, 2026 · PreprintCell Biology