Coordinated Tuning of Ionizable Lipids and Formulation Redirects mRNA Vaccines Toward Lymphoid-Specific CD4+ T Cell Immunity
Yeji Lee, Yelim Choi, Seongryong Kim, Jinah Yeo, Junghwa Lee, Eun Hye Jeong, Jeong Hun Kwak, Min-Sung Kang, Ha‐Eun Hong, Ok‐Hee Kim, Yun-Ho Hwang, J Park, Eui Ho Kim, Say‐June Kim, You-Jin Kim, Hyukjin Lee
This study shows that modifying ionizable lipids and formulation parameters of mRNA vaccines can enhance CD4+ T cell immunity and improve vaccine efficacy.
bioRxiv · Apr 18, 2026 · PreprintBioengineering