TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae
Sarah R. Chadwick, Samuel Stack-Couture, Matthew D. Berg, Sonja E. Di Gregorio, Bryan Lung, Julie L. Genereaux, Robyn D. Moir, Christopher J. Brandl, Ian M. Willis, Erik L. Snapp, Patrick Lajoie
This study shows TUDCA reduces drug bioavailability, not directly aiding protein folding, and rescues yeast from ER stress by sequestering toxic compounds.
Molecular Biology of the Cell · Dec 11, 2024Peer-reviewedCell Biology