Author

Samuel Stack-Couture

Western University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:C. elegans· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Julie L. Genereaux· 3 shared Patrick LajoieiD· 3 shared Bryan Lung· 2 shared Rebecca S. ShapiroiD· 2 shared Vanessa DumeauxiD· 2 shared Anna Kalabina· 1 shared Christopher J. BrandliD· 1 shared Erik L. SnappiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

Julie L. Genereaux

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3 papers

Recent·Most cited

Differential requirement for the Ire1 luminal domain in Candida albicans drug susceptibility and pathogenicity

Samuel Stack-Couture, Nathan Towriss, Iwona Skulska, Anna Kalabina, Julie L. Genereaux, Vanessa Dumeaux, Rebecca S. Shapiro, Patrick Lajoie

This study shows that the luminal domain of Ire1 in C. albicans is critical for cell wall integrity, thermal stress, and virulence, while the transmembrane domain is sufficient for azole antifungal tolerance.

bioRxiv · Sep 28, 2026 · PreprintCell Biology

Distinct Ire1-driven transcriptional responses control morphogenesis in Candida albicans

Samuel Stack-Couture, Gabriela Nunes Marsiglio-Librais, Bryan Lung, Julie L. Genereaux, Viola Halder, Vanessa Dumeaux, Rebecca S. Shapiro, Patrick Lajoie

This study identifies Ire1-driven transcriptional responses distinct from the canonical UPR in C. albicans, revealing HAC1-independent pathways and RIDD activity in morphogenesis.

Journal of Cell Science · Jun 17, 2026Peer-reviewedCell Biology

TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae

Sarah R. Chadwick, Samuel Stack-Couture, Matthew D. Berg, Sonja E. Di Gregorio, Bryan Lung, Julie L. Genereaux, Robyn D. Moir, Christopher J. Brandl, Ian M. Willis, Erik L. Snapp, Patrick Lajoie

This study shows TUDCA reduces drug bioavailability, not directly aiding protein folding, and rescues yeast from ER stress by sequestering toxic compounds.

Molecular Biology of the Cell · Dec 11, 2024Peer-reviewedCell Biology