Julie L. Genereaux

Differential requirement for the Ire1 luminal domain in Candida albicans drug susceptibility and pathogenicity

This study shows that the luminal domain of Ire1 in C. albicans is critical for cell wall integrity, thermal stress, and virulence, while the transmembrane domain is sufficient for azole antifungal tolerance.

Distinct Ire1-driven transcriptional responses control morphogenesis in Candida albicans

This study identifies Ire1-driven transcriptional responses distinct from the canonical UPR in C. albicans, revealing HAC1-independent pathways and RIDD activity in morphogenesis.

TUDCA modulates drug bioavailability to regulate resistance to acute ER stress in Saccharomyces cerevisiae

This study shows TUDCA reduces drug bioavailability, not directly aiding protein folding, and rescues yeast from ER stress by sequestering toxic compounds.

Anticodon sequence determines the impact of mistranslating tRNAAla variants

The paper investigates how anticodon mutations in tRNAAla affect yeast growth and mistranslation, finding that anticodon sequence influences mistranslation extent and growth impact.

Tra1 controls the transcriptional landscape of the aging cell

This study investigates the role of Tra1 in yeast chronological aging, finding it regulates stress response genes and mitochondrial function, impacting longevity.

Genetic background and mistranslation frequency determine the impact of mistranslating tRNASerUGG

This study shows that the impact of a mistranslating tRNA variant depends on genetic background and mistranslation frequency in yeast, with implications for understanding tRNA variants in human disease.

Regulating expression of mistranslating tRNAs by readthrough RNA polymerase II transcription

This paper develops an inducible tRNA system to study mistranslation effects in yeast by regulating tRNA expression through RNA polymerase II promoters.

The amino acid substitution affects cellular response to mistranslation

This study compares the effects of two tRNA variants causing different amino acid substitutions in yeast, showing distinct impacts on growth, heat shock response, and transcriptome changes.

Chemical-genetic interactions with the proline analog L-azetidine-2-carboxylic acid in Saccharomyces cerevisiae

The paper identifies genes with chemical-genetic interactions with AZC in yeast, revealing pathways involved in coping with amino acid mis-incorporation and proteotoxic stress.

Sfp1 regulates the SAGA component Tra1 in response to proteotoxic stress in Saccharomyces cerevisiae

The paper shows that Sfp1 regulates Tra1 expression in response to polyQ protein stress in yeast, linking TORC1 to SAGA complex function.