Patrick Lajoie

This study shows that the luminal domain of Ire1 in C. albicans is critical for cell wall integrity, thermal stress, and virulence, while the transmembrane domain is sufficient for azole antifungal tolerance.

This study identifies Ire1-driven transcriptional responses distinct from the canonical UPR in C. albicans, revealing HAC1-independent pathways and RIDD activity in morphogenesis.

The paper shows that adjusting extracellular pH to prevent acidification extends yeast lifespan by enhancing the heat shock response and promoting polyQ aggregation.

This study shows TUDCA reduces drug bioavailability, not directly aiding protein folding, and rescues yeast from ER stress by sequestering toxic compounds.

The paper investigates how Tra1 regulates azole resistance in different yeast species, finding species-specific effects on gene expression and drug tolerance.

This study investigates the role of Tra1 in yeast chronological aging, finding it regulates stress response genes and mitochondrial function, impacting longevity.

This paper develops an inducible tRNA system to study mistranslation effects in yeast by regulating tRNA expression through RNA polymerase II promoters.

The paper shows that Sfp1 regulates Tra1 expression in response to polyQ protein stress in yeast, linking TORC1 to SAGA complex function.