Eno Essien Ebong

The paper introduces two image-analysis pipelines to objectively quantify BBB integrity in vitro and in vivo, showing reduced ZO-1 fragment area and fragmentation ratio in glycocalyx knockdown models and altered markers in aged and Alzheimer's mice.

This study evaluates a therapy combining S1P and heparin to restore endothelial glycocalyx in disturbed flow conditions and improve vascular function.