Rebecca L. Pinals

The paper introduces two image-analysis pipelines to objectively quantify BBB integrity in vitro and in vivo, showing reduced ZO-1 fragment area and fragmentation ratio in glycocalyx knockdown models and altered markers in aged and Alzheimer's mice.

The paper constructs a 3D human brain model integrating multiple cell types to study Alzheimer's Disease mechanisms linked to APOE4.

A 16-hour continuous iodixanol density gradient workflow isolates lipid nanoparticle protein coronas from human plasma and shows that vitronectin and C-reactive protein coronas impair mRNA delivery in liver cells.

This study identifies an inflammation-driven gene module in brain endothelial cells that compromises BBB integrity in Alzheimer's disease and shows that an NF-κB inhibitor can reverse these effects.

The paper develops a 3D Brain-Chip system using human iPSC-derived cells to model the BBB and study APOE4's role in Alzheimer's disease.

The paper develops a stochastic model of dopamine dynamics in the striatal extracellular space to optimize fluorescent nanosensor design and imaging parameters for in vivo neuromodulation imaging.