Aβ-HMGB1 complex is a pathogenic molecule at the advanced stage of Alzheimer's disease
Hikari Tanaka, Hidenori Homma, Yuki Yoshioka, Kyota Fujita, Shingo Yamada, Katsutoshi Furukawa, Aiko Ishiki, Naoki Atsuta, Masaaki Waragai, Tatsuo Mano, Masahisa Katsuno, Gen Sobue, Hiroyuki Arai, Atsushi Iwata, Hitoshi Okazawa
This study identifies the Aβ-HMGB1 complex as a pathogenic factor in advanced Alzheimer's disease, showing it causes neuronal damage and that targeting HMGB1 improves symptoms in mouse models.
bioRxiv · Jun 12, 2025 · PreprintNeuroscience