Tatsuo Mano

This study identifies the Aβ-HMGB1 complex as a pathogenic factor in advanced Alzheimer's disease, showing it causes neuronal damage and that targeting HMGB1 improves symptoms in mouse models.

This study identifies LAMP2B as a mediator of microlipophagy, showing its role in preventing obesity and related metabolic disorders through enhanced lipid hydrolysis.

This paper develops a deep learning-based method to quantify gait features and estimate cadence from home-recorded videos of normal and parkinsonian gait.