Ronghu Wu

This study shows that USP37 prevents premature TRAIP-mediated disassembly of stalled replisomes, maintaining genome stability under replication stress.

This study shows that single-strand breaks cause replisome disassembly by generating different fork collapse structures depending on the strand, with CMG being passively removed during leading strand collapse and actively unloaded during lagging strand collapse.

The paper demonstrates that Fe2+ cleaves RNA via a non-oxidative in-line mechanism, is more reactive than Mg2+, and is stably associated with ribosomes under anaerobic conditions.