Author

Laura E. McCoy

University College LondonORCID 0000-0001-9503-7946Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Chloe Rees-SpeariD· 2 shared Emma TouizeriD· 2 shared Luke MuiriD· 2 shared Ravindra K. GuptaiD· 2 shared Sarah A. Griffith· 2 shared Áine McKnightiD· 1 shared Alasdair J. LeslieiD· 1 shared Alex SigaliD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

Chloe Rees-SpearORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Multifaceted B-cell response to transient HIV viraemia in elite controllers

Luke Muir, Ondřej Suchánek, Peter Thomas, Sarah A. Griffith, Emma Touizer, Chloe Rees-Spear, Robert Krause, Masahiro Yoshida, Christopher L. Pinder, Rutuja Patil, Marko Nikolić, Katie J. Doores, Marit J. van Gils, Alasdair J. Leslie, Alex Sigal, , Laura E. McCoy

This study investigates the B-cell response to transient HIV viraemia in elite controllers, revealing TLM heterogeneity and the role of innate-like B cells.

PLoS Pathogens · Jan 16, 2026Peer-reviewedImmunology

Auto-antibodies against interferons are common in people living with chronic hepatitis B virus infection and associate with PegIFN non-response

Douglas Fink, David Etoori, Robert Hill, Orest Idilli, Nikita Kartikapallil, Olivia Payne, Sarah A. Griffith, Hannah F. Bradford, Claudia Mauri, Patrick T.F. Kennedy, Laura E. McCoy, Mala K. Maini, Upkar S. Gill

This study finds that auto-antibodies against interferons are common in chronic hepatitis B patients and linked to PegIFN treatment non-response.

JHEP Reports · Feb 28, 2025Peer-reviewedImmunology

Preservation of memory B cell homeostasis in an individual producing broadly neutralising antibodies against HIV-1

Sarah Griffith, Luke Muir, Ondrej Suchanek, Joshua Hope, Corinna Pade, Joseph M Gibbons, Zewen Kelvin Tuong, Audrey Fung, Emma Touizer, Chloe Rees-Spear, Andrea Nans, Chloe Roustan, Yilmaz Alguel, Douglas Fink, Chloe Orkin, , Laura E McCoy

The paper isolates a broadly neutralizing HIV-1 antibody from an untreated HIV-1 patient and shows memory B cells remain functional despite viral infection.

bioRxiv · Feb 5, 2024 · PreprintMicrobiology