Author

Devin Clegg

Yale UniversityORCID 0000-0001-9522-168XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Agnes Roczniak-FergusoniD· 1 shared Amanda Bentley‐DeSousaiD· 1 shared Shawn M. FergusoniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperCell Biology

Agnes Roczniak-FergusonORCID

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1 paper

Recent·Most cited

Cell BiologybioRxivPreprintNov 19, 2025

ClC-7 links PIKfyve inhibition to Rab-dependent LRRK2 activity at lysosomes

Devin Clegg, Amanda Bentley‐DeSousa, Agnes Roczniak-Ferguson, Shawn M. Ferguson

This study shows that PIKfyve inhibition enhances LRRK2 signaling via ClC-7-dependent lysosomal remodeling and Rab accumulation, revealing distinct Rab and GABARAP inputs for LRRK2 activation under different lysosomal stresses.

4 citations

humanproteomics

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