Author

Agnes Roczniak-Ferguson

Yale UniversityORCID 0000-0003-0838-2157Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Shawn M. FergusoniD· 2 shared Amanda Bentley‐DeSousaiD· 1 shared Devin CleggiD· 1 shared Hongying SheniD· 1 shared Layla M. NassariD· 1 shared Xiaojian ShiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 9 mutual co-author links

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2 shared papersCell Biology

Shawn M. FergusonORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintNov 19, 2025

ClC-7 links PIKfyve inhibition to Rab-dependent LRRK2 activity at lysosomes

Devin Clegg, Amanda Bentley‐DeSousa, Agnes Roczniak-Ferguson, Shawn M. Ferguson

This study shows that PIKfyve inhibition enhances LRRK2 signaling via ClC-7-dependent lysosomal remodeling and Rab accumulation, revealing distinct Rab and GABARAP inputs for LRRK2 activation under different lysosomal stresses.

4 citations

humanproteomics

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Cell BiologybioRxivPreprintJun 6, 2025

JIP4 deficiency causes a novel lysosome storage disease arising from impaired cystine efflux

Layla M. Nassar, Xiaojian Shi, Agnes Roczniak-Ferguson…·Shawn M. Ferguson

This study shows that JIP4 deficiency causes lysosomal cystine accumulation by reducing CTNS levels, mimicking cystinosis in human cells and mice.

DOI 10.1101/2025.06.06.657909

humanmouse

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