Amanda Bentley‐DeSousa

ClC-7 links PIKfyve inhibition to Rab-dependent LRRK2 activity at lysosomes

This study shows that PIKfyve inhibition enhances LRRK2 signaling via ClC-7-dependent lysosomal remodeling and Rab accumulation, revealing distinct Rab and GABARAP inputs for LRRK2 activation under different lysosomal stresses.

Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C

The paper shows that VPS13C senses lysosome damage, relocates to lysosomes, and tethers them to the ER, suggesting a protective lipid transport response.

Vtc5 is localized to the vacuole membrane by the conserved AP-3 complex to regulate polyphosphate synthesis in budding yeast

The paper shows that the AP-3 complex is required for Vtc5 localization to the vacuole membrane in yeast, and its mislocalization leads to decreased polyP levels.

Proteins required for vacuolar function are targets of lysine polyphosphorylation in yeast

The paper identifies 8 new polyphosphorylated proteins in yeast, including vacuolar proteins, and suggests a feedback regulation model for polyP synthesis.