DNA damage at Lamina-Associated Domains triggers nuclear envelope reorganization and chromatin detachment to prevent nuclear envelope blebbing and genome instability.
Diana Rubio-Contreras, Sylvain Audibert, Joanna Fernández…·Evi Soutoglou
Author
Universidade de Santiago de CompostelaORCID 0000-0001-9542-0013Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Diana Rubio-Contreras, Sylvain Audibert, Joanna Fernández…·Evi Soutoglou
Lucia Ramos-Lage, Cristina Ameneiro, David Martinez-Delgado…·Diana Guallar
This study shows that GEN1 is essential for mouse embryonic stem cell self-renewal and genome stability, with a non-enzymatic role in maintaining pluripotency.
Raquel Carreira, Tomás Lama-Díaz, Maria Crugeiras…·Miguel G. Blanco
The paper shows that Mus81 and Yen1 cleave D-loops to form half-crossover precursors in budding yeast.
Raquel Carreira, F. Javier Aguado, Vanesa Hurtado-Nieves, Miguel G. Blanco
This study characterizes Yen1, a Holliday junction resolvase, revealing both canonical and novel non-canonical activities in vitro.