Author

Diana Rubio-Contreras

Instituto de Biomedicina de SevillaORCID 0000-0003-4828-4906Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Evi SoutoglouiD· 2 shared Fernando Gómez-HerrerosiD· 2 shared Raquel CarreiraiD· 2 shared Alba CoegoiD· 1 shared Alejandro Fuentes-IglesiasiD· 1 shared Anne‐Claude GingrasiD· 1 shared Arne Nedergaard KousholtiD· 1 shared Atina G. CotéiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

Evi SoutoglouORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cell BiologybioRxivPreprintOct 27, 2026

DNA damage at Lamina-Associated Domains triggers nuclear envelope reorganization and chromatin detachment to prevent nuclear envelope blebbing and genome instability.

Diana Rubio-Contreras, Sylvain Audibert, Joanna Fernández…·Evi Soutoglou

DOI 10.64898/2026.10.25.761546

humanDNA methylation

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Cell BiologybioRxivPreprintJul 23, 2026

The Holliday junction resolvase GEN1 preserves genome integrity and self-renewal in mouse embryonic stem cells

Lucia Ramos-Lage, Cristina Ameneiro, David Martinez-Delgado…·Diana Guallar

This study shows that GEN1 is essential for mouse embryonic stem cell self-renewal and genome stability, with a non-enzymatic role in maintaining pluripotency.

DOI 10.64898/2026.07.23.740277

mousegenetic perturbation / CRISPR

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GeneticsCell Death and DiseasePeer-reviewedNov 28, 2025

SCAN1 mutant TDP1 blocks the repair of DSB induced by TOP1 activity during gene transcription and promotes genome reorganisations and cell death in quiescent cells

Diana Rubio-Contreras, Daniel Hidalgo-García, Carmen Angulo-Jiménez…·Fernando Gómez-Herreros

This study shows that the SCAN1 mutation H493R in TDP1 blocks repair of TOP1-induced DSBs in quiescent cells, leading to genome instability and cell death.

DOI 10.1038/s41419-025-08085-y

humanexperimental assay

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Molecular BiologybioRxivPreprintSep 23, 2022

Genome-scale mapping of DNA damage suppressors identifies GNB1L as essential for ATM and ATR biogenesis

Yichao Zhao, Daniel R. Tabet, Diana Rubio-Contreras…·Daniel Durocher

The paper identifies 160 genes that suppress DNA damage in human cells through CRISPR/Cas9 screens, highlighting GNB1L's role in ATR biogenesis and its link to neuropsychiatric disorders.

DOI 10.1101/2022.09.23.508845

humanCRISPR screen

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