Miguel G. Blanco

The Holliday junction resolvase GEN1 preserves genome integrity and self-renewal in mouse embryonic stem cells

This study shows that GEN1 is essential for mouse embryonic stem cell self-renewal and genome stability, with a non-enzymatic role in maintaining pluripotency.

Cx43 Enhances Response to BRAF/MEK Inhibitors by Reducing DNA Repair Capacity

This study shows that Cx43 enhances the effectiveness of BRAF/MEKi by reducing DNA repair, leading to increased DNA damage and cellular senescence, and proposes a novel therapeutic approach using sEVs.

Concurrent D-loop cleavage by Mus81 and Yen1 yields half-crossover precursors

The paper shows that Mus81 and Yen1 cleave D-loops to form half-crossover precursors in budding yeast.

Alternative translation initiation by ribosomal leaky scanning produces multiple isoforms of the Pif1 helicase

The paper shows that ribosomal leaky scanning generates multiple Pif1 helicase isoforms in budding yeast through alternative translation initiation from two consecutive AUG codons.

Canonical and novel non-canonical activities of the Holliday junction resolvase Yen1

This study characterizes Yen1, a Holliday junction resolvase, revealing both canonical and novel non-canonical activities in vitro.

Pan-cancer analysis of whole genomes reveals driver rearrangements promoted by LINE-1 retrotransposition in human tumours

The paper analyzes somatic retrotransposition events in 2,954 cancer genomes, identifying L1 insertions as significant contributors to structural variations and oncogenesis.