Author

Sarah Scharfenberg

Essen University HospitalORCID 0000-0001-9616-3493Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander RoeschiD· 2 shared Daniel Robert EngeliD· 2 shared A. Hoewner· 1 shared Alpaslan TasdoganiD· 1 shared Annette PascheniD· 1 shared Barbara T. GrünwaldiD· 1 shared Batool Shannan· 1 shared Bente SiebelsiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Alexander RoeschORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintApr 13, 2026

Lactate-dependent metabolic rewiring is associated with CD163+ macrophage polarization in human pyelonephritis

Lars Borgards, Hannah Voß, Stephanie Tautges…·Daniel Robert Engel

This study identifies lactate as a metabolic driver of CD163+ macrophage polarization in human pyelonephritis, linking lactate metabolism to immune dysfunction.

DOI 10.64898/2026.04.09.717269

humanproteomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMar 10, 2025

Redirecting resistance evolution in BRAFV600 melanoma by inhibition of the peroxiredoxin-thioredoxin system

Stefanie Egetemaier, Heike Chauvistré, Renáta Váraljai…·Alexander Roesch

This study identifies KDM5B's role in regulating the PRDX/TXN ROS detoxification system in melanoma DTPs, showing that PRDX inhibition increases ROS vulnerability and delays resistance to MAPK inhibition.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky