Functional analysis of conserved C. elegans bHLH family members uncovers lifespan control by a peptidergic hub neuron
G. Robert Aguilar, Berta Vidal, Hongzhu Ji…·Oliver Hobert
The paper identifies the role of C. elegans bHLH genes in specifying neuron identity and function, revealing that hlh-15/NHLH controls lifespan through neuropeptide secretion in AVK neurons.