Christopher M. Fang-Yen

An automated genetic screen identifies modulators of stress-induced sleep in Caenorhabditis elegans

The paper identifies genes modulating stress-induced sleep in C. elegans using automated screening and genetic association analysis.

Mechanisms of surface and volume light scattering from Caenorhabditis elegans revealed by angle-resolved measurements

This study investigates light scattering mechanisms in C. elegans using angle-resolved measurements and simulations, identifying surface and volume scattering components and their impact on image contrast.

A switch in arousal circuit architecture shapes sleep across the lifespan

The paper identifies distinct octopaminergic neuron populations in Drosophila that drive arousal in larvae and adults, revealing a developmental switch in sleep-wake circuit architecture.

Functional analysis of conserved C. elegans bHLH family members uncovers lifespan control by a peptidergic hub neuron

The paper identifies the role of C. elegans bHLH genes in specifying neuron identity and function, revealing that hlh-15/NHLH controls lifespan through neuropeptide secretion in AVK neurons.

Automated multimodal imaging of Caenorhabditis elegans behavior in multi-well plates

This paper develops an automated imaging system for C. elegans behavior analysis and identifies serotonin's role in egg-laying and locomotion.

Segmentation-free measurement of locomotor frequency in Caenorhabditis elegans using image invariants

This paper introduces an image invariant-based method to measure C. elegans locomotor frequency without segmentation, showing improved robustness to low image quality and background noise.

A proprioceptive feedback circuit controls Caenorhabditis elegans locomotor amplitude through dopamine signaling

The paper identifies a proprioceptive feedback circuit in C. elegans that adjusts locomotor amplitude via dopamine and neuropeptide signaling.

Pharyngeal timing and particle transport defects in Caenorhabditis elegans feeding mutants

This study examines pharyngeal pumping defects in C. elegans feeding mutants using high-speed video microscopy to identify specific timing and contraction issues affecting particle transport.

Phase response analyses support a relaxation oscillator model of locomotor rhythm generation in Caenorhabditis elegans

The paper uses phase response analysis to support a relaxation oscillator model explaining C. elegans locomotor rhythm generation.

DAF-16/FoxO and DAF-12/VDR control cellular plasticity both cell-autonomously and via interorgan signaling

The paper shows that DAF-16/FoxO and DAF-12/VDR control cellular plasticity both cell-autonomously and through interorgan signaling in C. elegans.

Thermal laser ablation with tunable lesion size reveals multiple origins of seizure-like convulsions in Caenorhabditis elegans

This study uses thermal laser ablation in C. elegans to investigate the origins of seizure-like convulsions in a gain-of-function mutant.

Sleep Induction by Mechanosensory Stimulation in Drosophila

This study shows gentle vibration promotes sleep in Drosophila through habituation, with sleep induction improving over time and showing stimulus specificity.

Sleep is required for odor exposure to consolidate memory and remodel olfactory synapses

The paper shows that sleep is necessary for memory consolidation and synaptic remodeling in C. elegans after odor training.

Preconditioning of Caenorhabditis elegans to Anoxic Insult by Inactivation of Cholinergic, GABAergic, and Muscle Activity

This study shows that inactivating the nervous system and muscles in C. elegans before an anoxic insult increases resistance to prolonged anoxia.

Dehydrated Caenorhabditis elegans stocks are resistant to multiple freeze-thaw cycles

This study shows that dehydrated C. elegans stocks can survive multiple freeze-thaw cycles using trehalose or glycerol.

A quiescent state following mild sensory arousal in Caenorhabditis elegans is potentiated by stress

The paper identifies a quiescent state in C. elegans, PRQ, which is enhanced by cellular stress and involves neuropeptidergic mechanisms but is not sleep.

Distributed Rhythm Generators Underlie Caenorhabditis elegans Forward Locomotion

The paper identifies multiple rhythm generators in C. elegans forward locomotion through optogenetic and ablation experiments, showing coordinated oscillations between body regions.

Excitatory Motor Neurons are Local Central Pattern Generators in an Anatomically Compressed Motor Circuit for Reverse Locomotion

The paper identifies class A motor neurons in C. elegans as intrinsic oscillators driving reverse locomotion without premotor interneurons.