Hervé Isambert

This study identifies the pentose phosphate pathway's role in regulating myeloid versus lymphoid lineage specification in hematopoietic stem and progenitor cells through metabolic state-fate mapping.

The paper shows clonal memory in human HSPCs persists across divisions and is disrupted in AML, with potential for therapeutic modulation.

This paper develops a label-free platform combining microfluidics, morphological analysis, and machine learning to predict chemotherapy effects on tumor spheroids, showing robust performance across cell lines and patient-derived samples.

CausalXtract identifies causal effects in live-cell imaging data by combining network and information-based frameworks, revealing novel interactions in tumor-on-chip systems.

This study shows that macrophages control collagen network topography via Tcf4-Collagen3 pathway, influencing immune cell infiltration in tumors.

OHNOLOGS v2 identifies and refines ohnologs from 2R- and 3R-WGD in 27 vertebrate genomes, revealing retention patterns across species.