Kellen L. Olszewski

This study investigates the effects of O-GlcNAc depletion on lipid metabolism and shows that it leads to lipid remodeling and increased sensitivity to ferroptosis.

The paper uses in vivo isotope tracing and AI to identify biosynthetic origins of unknown metabolites, revealing new metabolic pathways and age-related changes.

The paper shows that mammalian cells produce certain indole and phenol metabolites, while bacterial metabolism is required for others, highlighting host contributions to circulating pools.

This study shows that supplementing one-carbon units enhances anti-PD-1 checkpoint blockade by supporting purine synthesis in tumor-infiltrating T cells, leading to increased durable tumor regression.