Keith W. Nehrke

This study shows that the TWK-26/KCNK3 potassium channel and FLR-4 protein kinase work together in C. elegans to regulate nutrient absorption and metabolic homeostasis.

This study shows that clearing tau proteins in C. elegans reverses neuronal dysfunction in both young and aged worms, suggesting potential for AD therapies targeting soluble tau.

The paper shows that phosphomimetic tau mutants inhibit mitophagy by reducing FKBP8 levels during oxidative stress in neuronal cells.

This study shows that specific phosphorylation sites on tau affect mitochondrial function and stress responses in neuronal cells.

This paper develops a C. elegans model to study how specific tau modifications contribute to neurodegeneration and mitophagy in Alzheimer's disease.