Emily Chen

The basal cell state maintains pancreatic cancers by controlling an immunosuppressive circuit

This study identifies the basal cell state in pancreatic cancer as critical for maintaining tumors through an immunosuppressive circuit, showing its ablation leads to tumor collapse.

Prenatal circadian rhythm disruption induces sex-specific substance use and mood-related phenotypes in mice

This study shows that prenatal circadian rhythm disruption in mice leads to sex-specific behavioral changes in adulthood, with females showing mood-related issues and males showing substance use-like behaviors.

Spatially Distinct Myosin II Architectures Regulate Protrusion Dynamics and Directional Persistence during Immune Cell Migration

This study identifies two spatially distinct myosin II architectures in neutrophils that coordinate protrusion dynamics and directional persistence during migration.

Myeloid States Predict Fate of Premalignant Lesions

The paper tracks premalignant lesions in head and neck cancer using intravital microscopy and identifies myeloid cell organization as a predictor of lesion regression or progression.

Tau phosphorylation suppresses oxidative stress-induced mitophagy via FKBP8 receptor modulation

The paper shows that phosphomimetic tau mutants inhibit mitophagy by reducing FKBP8 levels during oxidative stress in neuronal cells.

mosGraphFlow: a novel integrative graph AI model mining disease targets from multi-omic data

This study introduces mosGraphFlow, a graph AI model for analyzing multi-omic data to identify AD-associated biomarkers and signaling pathways, achieving high classification accuracy.

mosGraphGPT: a foundation model for multi-omic signaling graphs using generative AI

mosGraphGPT is a foundation model for multi-omic signaling graphs trained on cancer data and fine-tuned for Alzheimer's Disease, improving classification accuracy and interpretability.

The SMC5/6 complex is required for maintenance of genome integrity upon APOBEC3A-mediated replication stress

This study identifies the SMC5/6 complex as essential for genome stability in cells with active APOBEC3A, showing that its loss leads to increased DNA damage and replication stress.

Recombinant expression of Proteorhodopsin and biofilm regulators in Escherichia coli for nanoparticle binding and removal in a wastewater treatment model

This paper demonstrates the use of genetically modified Escherichia coli to bind and remove nanoparticles in wastewater treatment through Proteorhodopsin and biofilm production.