Konstantinos Arfanakis

This study investigates how microglial inflammation affects hippocampal volume in relation to AD and LATE-NC, finding that microglia enhance LATE-NC's impact on volume loss but not AD.

This study identifies genetic loci and pathways associated with limbic white matter microstructure in aging and Alzheimer's Disease using multi-cohort diffusion MRI and bulk RNA-seq data.

This study identifies molecular predictors of neuronal dysfunction in Alzheimer's disease by analyzing E/I imbalance and its relationship with neuropathology.

This study translates post-mortem brain multi-omics AD dementia subtypes into blood, MRI, and psychological markers in living individuals.

The paper examines associations between three multi-omic AD subtypes and four psychological traits, finding differential links between subtypes and traits.

The paper describes the neuroimaging component of the A2CPS project, detailing data collection, processing, and initial findings linking brain measures to clinical variables.

The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

The paper examines how sex, race, and APOE-ε4 allele status affect white matter microstructure across multiple aging and Alzheimer's disease cohorts.

This study identifies 67 genetic loci associated with head size, finding strong overlaps with cancer pathways and genes, suggesting shared genetic mechanisms between head growth and cancer risk.

The paper identifies two subtypes of aging brains with distinct Alzheimer's risk profiles and differential impacts of APOEε4.

The paper identifies 25 genetic loci associated with subcortical brain structure volumes in over 40,000 individuals, revealing novel biology and potential drug targets.