Derrek P. Hibar

SPEX provides a web-based platform for spatial omics analysis, enabling modular and user-friendly processing of spatial transcriptomics and proteomics data.

The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

The paper identifies microglial activation as a factor contributing to cortical thinning in epilepsy by integrating neuroimaging and gene expression data.

The paper analyzes cortical thickness trajectories in 17,075 individuals to show peak thickness in childhood, steep decline in early adulthood, and slower decline later, with notable exceptions and significant inter-individual variability.

This study identifies genetic variants influencing human cortical surface area by integrating evolutionary annotations with neuroimaging genetic data, revealing recent polygenic selection on brain regions involved in language and vision.

This study analyzes subcortical volume changes across the lifespan using MRI data from 18,605 individuals, finding age-related declines in some structures and increases in others.

The paper identifies genetic loci associated with human cortical structure and finds genetic correlations with neuropsychiatric disorders.

The paper identifies 161 genome-wide significant genetic associations for cortical structure traits across 34 brain regions, highlighting key biological pathways and gene functions.

The paper identifies genetic associations with cortical surface area using PCA and GWAS, linking DAAM1 to visual cortex development through mitochondrial pathways and thalamocortical input.

This study identifies genetic overlaps between Tourette Syndrome risk and subcortical brain volumes using GWAS and pleiotropy analysis.

The paper identifies genetic correlations between ADHD and brain volumes, finding negative associations with intracranial volume and specific brain regions.

The paper identifies 25 genetic loci associated with subcortical brain structure volumes in over 40,000 individuals, revealing novel biology and potential drug targets.