Aggregated α-synuclein leads to corticostriatal synaptic dysfunction
Charlotte F. Brzozowski, Harshita Challa, Nolwazi Z. Gcwensa…·Mark S. Moehle
This study shows that aggregated α-synuclein impairs corticostriatal synaptic function and reduces synaptic density in mice, with some synapses showing increased volume.