Douglas Nabert

Pathological α-Synuclein Perturbs Nuclear Integrity

This study shows pathological α-synuclein localizes in the nucleus, causing nuclear damage and dysfunction in synucleinopathy models and human tissue.

Aggregated α-synuclein leads to corticostriatal synaptic dysfunction

This study shows that aggregated α-synuclein impairs corticostriatal synaptic function and reduces synaptic density in mice, with some synapses showing increased volume.

Conditional Knockout of Striatal Gnal Produces Dystonia-like Motor Phenotypes

Knocking out Gnal in the striatum of mice leads to dystonia-like motor symptoms and increased excitability in striatal spiny projection neurons.