Dominic Hall

CROP-1 predicts gene activity based on DNA sequence and regulatory state, enabling context-specific edit design in plants with higher accuracy than sequence-only models.

This study investigates the potential of M5 positive allosteric modulators to alleviate parkinsonian motor deficits without causing dyskinesia or impairing L-DOPA efficacy.

This study shows pathological α-synuclein localizes in the nucleus, causing nuclear damage and dysfunction in synucleinopathy models and human tissue.

This study shows that aggregated α-synuclein impairs corticostriatal synaptic function and reduces synaptic density in mice, with some synapses showing increased volume.

Knocking out Gnal in the striatum of mice leads to dystonia-like motor symptoms and increased excitability in striatal spiny projection neurons.

This study characterizes Gnal expression in the mouse brain and shows its role in motor-related neurons through conditional knockout experiments.

The paper studies 3D genome structure changes in single mouse ES cells exiting pluripotency, finding reorganization of enhancer-promoter interactions through multiway chromatin hubs.

Graphein transforms bioinformatics data into machine learning-ready graph representations for geometric deep learning and network analysis.