The paper identifies unique transcriptional profiles of immature neurons in aged human hippocampus across healthy, Alzheimer's disease, and resilient conditions, linking them to homeostasis and cognitive resilience.

Cell stem cell · Apr 24, 2026Peer-reviewedNeuroscience

Long noncoding RNA MEG3 activates neuronal necroptosis in Alzheimer's disease

Sriram Balusu, Katrien Horré, Nicola Thrupp, An Snellinx, Lutgarde Serneels, Iordana Chrysidou, Amaia M. Arranz, Annerieke S. R. Sierksma, Joel Simrén, Thomas K. Karikari, Henrik Zetterberg, Wei-Ting Chen, Dietmar Rudolf Thal, Evgenia Salta, Mark W. E. J. Fiers, Bart De Strooper

The paper shows that MEG3, a long noncoding RNA, induces necroptosis in human neurons exposed to amyloid pathology, mimicking AD features in a xenograft model.

bioRxiv · Feb 18, 2022 · PreprintNeuroscience

Spatial and temporal transcriptomics reveal microglia-astroglia crosstalk in the amyloid-β plaque cell niche of Alzheimer’s disease

Wei-Ting Chen, Ashley Lu, Katleen Craessaerts, Benjamin Pavie, Carlo Sala Frigerio, Nikky Corthout, Xiaoyan Qian, Jana Laláková, Malte Kühnemund, Iryna Voytyuk, Leen Wolfs, Renzo Mancuso, Evgenia Salta, Sriram Balusu, An Snellinx, , Bart De Strooper

The paper uses spatial transcriptomics and in situ sequencing to study gene networks in the amyloid-β plaque niche of AD, revealing microglia-astroglia interactions and myelination abnormalities.

Cell · Jul 22, 2020Peer-reviewedNeuroscience

Impaired adult hippocampal neurogenesis in Alzheimer's disease is mediated by microRNA-132 deficiency and can be restored by microRNA-132 replacement

Evgenia Salta, Hannah Walgrave, Sriram Balusu, Elke Vanden Eynden, Sarah Snoeck, Katleen Craessaerts, Nicola Thrupp, Leen Wolfs, Katrien Horré, Yannick Fourne, Alicja Ronisz, Edina Silajdžić, Zsuzsanna Callaerts‐Vegh, Rudi D’Hooge, Dietmar Rudolf Thal, , Bart De Strooper

This study identifies miR-132 deficiency as a cause of impaired adult hippocampal neurogenesis in Alzheimer's disease and shows that restoring miR-132 levels can reverse these deficits and memory issues.

bioRxiv · Mar 12, 2020 · PreprintNeuroscience

Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology

Annerieke S. R. Sierksma, Ashley Lu, Renzo Mancuso, Nicola Fattorelli, Nicola Thrupp, Evgenia Salta, Jesús Zoco, David L Blum, Luc Buée, Bart De Strooper, Mark W. E. J. Fiers

The paper identifies AD risk genes that influence microglia response to amyloid-β but not TAU pathology in mouse models.

EMBO Molecular Medicine · Jan 17, 2020Peer-reviewedNeuroscience