Natural Killer Cell Dysfunction In Human Bladder Cancer Is Caused By Tissue-Specific Suppression of SLAMF6 Signaling
Adam M. Farkas, Dina Youssef, Michelle A. Tran, Sreekumar Balan, Jenna H. Newman, François Audenet, Harry Anastos, Leandra G. Velazquez, Ante Peros, Aparna Ananthanarayanan, Jorge Daza, Elena González-Gugel, Keerthi Caroline Sadanala, Jakob Theorell, Matthew D. Galsky, , Nina Bhardwaj
This study identifies SLAMF6 signaling suppression in bladder cancer tumor microenvironment as a cause of NK cell dysfunction, showing restoration of function under normoxic conditions.
bioRxiv · Apr 30, 2024 · PreprintImmunology