Author

Leandra G. Velazquez

Tisch Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 3 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1

Frequent Co-Authors

Nina BhardwajiD· 3 shared Aparna AnanthanarayananiD· 2 shared Cansu Cimen BozkusiD· 2 shared Matthew BrowniD· 2 shared Nicolas VabretiD· 2 shared Adam M. FarkasiD· 1 shared Alexander W. CharneyiD· 1 shared Amir HorowitziD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

Nina BhardwajORCID

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Author profile →

4 papers

Recent·Most cited

Coordinated macrophage and T cell interactions mediate response to checkpoint blockade in colorectal cancer.

Guillaume Mestrallet, Matthew Brown, Natalie Vaninov, Nam Woo Cho, Leandra G. Velazquez, Aparna Ananthanarayanan, Matthew H. Spitzer, Nicolas Vabret, Cansu Cimen Bozkus, Robert M. Samstein, Nina Bhardwaj

This study identifies T cell and macrophage subsets that mediate response to anti-PD-1 therapy in colorectal cancer, showing that combination therapy can eradicate tumors in both MMRd and MMRp settings.

Cell Reports Medicine · May 1, 2026Peer-reviewedImmunology

A Versatile AAV-TH-SNCA Model to Study Early α-Synuclein Pathology and Intervention

Sabina Marciano, Leandra G. Velazquez, Claudia Rodríguez López, Neranjan de Silva, Garrett Sommer, William Tower, Eileen Ruth S. Torres, Michael G. Kaplitt, Teresa A. Milner, Roberta Marongiu

This paper develops an optimized AAV.TH.SNCA model to study early α-synuclein pathology in mice, showing that motor deficits and neurochemical changes occur before neuronal loss.

bioRxiv · Apr 30, 2026 · PreprintNeuroscience

T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome.

Cansu Cimen Bozkus, Matthew Brown, Leandra G. Velazquez, Marcus Thomas, Eric A. Wilson, Timothy J. O’Donnell, Anna Kaminska, Denis Ruchnewitz, Douglas Geertz, Yonina Bykov, Julia Kodysh, Kasopefoluwa Y. Oguntuyo, Vladimir Roudko, David Hoyos, Komal Srivastava, , Nina Bhardwaj

The paper maps T cell epitopes in SARS-CoV-2, showing that immunodominant regions are conserved across variants and important for immune surveillance.

iScience · Jul 2, 2025Peer-reviewedImmunology

Natural Killer Cell Dysfunction In Human Bladder Cancer Is Caused By Tissue-Specific Suppression of SLAMF6 Signaling

Adam M. Farkas, Dina Youssef, Michelle A. Tran, Sreekumar Balan, Jenna H. Newman, François Audenet, Harry Anastos, Leandra G. Velazquez, Ante Peros, Aparna Ananthanarayanan, Jorge Daza, Elena González-Gugel, Keerthi Caroline Sadanala, Jakob Theorell, Matthew D. Galsky, , Nina Bhardwaj

This study identifies SLAMF6 signaling suppression in bladder cancer tumor microenvironment as a cause of NK cell dysfunction, showing restoration of function under normoxic conditions.

bioRxiv · Apr 30, 2024 · PreprintImmunology