Author

Jorge Daza

Roswell Park Comprehensive Cancer CenterORCID 0000-0002-5476-3041Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Jorge Daza1 paper

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Amir HorowitziD· 2 shared Matthew D. GalskyiD· 2 shared A. Demetriou· 1 shared A. Narasimhan· 1 shared A. Rangel· 1 shared A. Tocheva· 1 shared A.M. FarkasiD· 1 shared Adam M. FarkasiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Amir HorowitzORCID

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2 papers

Recent·Most cited

The HLA-E/NKG2A axis identifies a therapeutic vulnerability in BCG-unresponsive bladder cancer

Bérengère Salomé, Haocheng Yu, Daniel L Ranti, Ying‐Chih Wang, C. Bieber, Pierre‐Etienne Gabriel, Igor Duquesne, Trine Strandgaard, B. Hug, Sean Houghton, Hiranmayi Ravichandran, Elliot Merritt, S. Bang, A. Demetriou, Z. Li, , Amir Horowitz

This study identifies the HLA-E/NKG2A axis as a therapeutic target in BCG-unresponsive bladder cancer by showing its role in immune evasion and impaired effector cell function.

bioRxiv · Sep 2, 2024 · PreprintCancer Biology

Natural Killer Cell Dysfunction In Human Bladder Cancer Is Caused By Tissue-Specific Suppression of SLAMF6 Signaling

Adam M. Farkas, Dina Youssef, Michelle A. Tran, Sreekumar Balan, Jenna H. Newman, François Audenet, Harry Anastos, Leandra G. Velazquez, Ante Peros, Aparna Ananthanarayanan, Jorge Daza, Elena González-Gugel, Keerthi Caroline Sadanala, Jakob Theorell, Matthew D. Galsky, , Nina Bhardwaj

This study identifies SLAMF6 signaling suppression in bladder cancer tumor microenvironment as a cause of NK cell dysfunction, showing restoration of function under normoxic conditions.

bioRxiv · Apr 30, 2024 · PreprintImmunology