Yuxin Li

The paper develops a multi-omics cohort of prefrontal cortex data from cognitively normal older adults to identify molecular signatures of cognitive resilience to Alzheimer's disease.

Alzheimer's mouse model proteomes capture 30% (amyloid-only models) to 42% (adding tau and splicing models) of consensus human AD protein changes; in 5xFAD, plaques slow degradation of plaque-associated proteins.

SMAP is a pipeline that matches proteomic and genomic samples using protein-coding variants and discriminant scores, correcting 18.8% of mismatches in a large-scale proteomics dataset.