Alyssa Erickson

The paper develops MPIRE to assess insulator activity across the genome, finding that insulators function in specific genomic contexts and depend on transcription factor binding.

This study identifies a functional interaction between MeCP2 and TOP2β in neurons, showing MeCP2 inhibits TOP2β activity at long genes, which may contribute to neurodevelopmental disorders.

This study examines how different DNMT3A mutations cause varied behavioral, epigenetic, and transcriptional issues in neurodevelopmental disorders.

SMAP is a pipeline that matches proteomic and genomic samples using protein-coding variants and discriminant scores, correcting 18.8% of mismatches in a large-scale proteomics dataset.