Jason C. Casler

This study identifies Mdm38/LETM1 as a protein that links ion homeostasis and proteostasis in the mitochondrial inner membrane in yeast.

The paper shows that balanced, reduced rates of mitochondrial fission and fusion maintain mtDNA integrity in yeast, and increased mtDNA copy number reduces respiratory loss in mutants.

The paper shows that increased neuronal excitation leads to the formation of Golgi satellites in dendrites, which modify surface glycoproteins and impact neurotransmitter receptor function.

The paper describes an improved FKBP mutant that forms aggregates dissolving more readily than the original FKBP(M) mutant when tested in yeast.