Aubrey V. Weigel

This study uses single-particle tracking and 3D FIB-SEM to reveal dynamics and organization of individual vimentin filaments within dense networks, showing bidirectional motion and minimal local co-alignment with microtubules.

The paper identifies periodic ER-PM junctions in dendrites that enable long-range Ca2+ signal integration through local spine activation and ryanodine receptor-dependent Ca2+ release.

The paper releases high-resolution 3D imaging and nucleus segmentations of seven tissues from a P7 mouse using FIB-SEM and machine learning.

The paper shows that increased neuronal excitation leads to the formation of Golgi satellites in dendrites, which modify surface glycoproteins and impact neurotransmitter receptor function.

This study shows that nicotine exposure and neuronal activity alter Golgi membrane distribution in neurons, affecting local trafficking and potentially contributing to addiction.

The paper shows that astrocytes detoxify fatty acids from hyperactive neurons through mitochondrial oxidation, protecting neurons from toxicity.