Cell BiologybioRxivPreprint
Cell-free mtDNA drives pyroptosis and inflammation in m.3243A>G mitochondrial disease models
Monica Moresco, Alessandro Rapone, Concetta Valentina Tropeano…·Alessandra Maresca
This study shows that the m.3243A>G mutation increases cell-free mtDNA release, triggering pyroptosis and inflammation in MELAS models.
DOI 10.64898/2026.06.03.729489