Ke Hu

Proteome-wide crosslinking mass spectrometry reveals novel components of essential complexes in Toxoplasma

The paper uses crosslinking mass spectrometry to map protein interactions in Toxoplasma gondii, identifying novel components of essential complexes and revealing structural diversity in mitochondrial machinery.

The human parasite, Toxoplasma gondii, is paralyzed without two components of the apical polar ring

This study identifies APR9 and KinesinA as essential components of the apical polar ring in Toxoplasma gondii, showing that their combined loss paralyzes the parasite and impairs key life cycle processes.

Transfection of the free-living alga Chromera velia enables direct comparisons with its parasitic apicomplexan relative, Toxoplasma gondii

This study enables the study of Chromera velia's biology by developing cell transformation and expansion microscopy techniques, revealing insights into its subcellular organization.

The initiation and early development of apical-basal polarity in Toxoplasma gondii

This study investigates the initiation and early development of apical-basal polarity in Toxoplasma gondii using expansion microscopy, revealing the synchronized development of apical and basal structures and the synergistic role of APR2 and KinesinA.