Marc E. Rothenberg

This study identifies a type 2 neuroimmune circuit involving IL-4 receptor-dependent DRG responses that modify esophageal inflammation in eosinophilic esophagitis.

The paper identifies epithelial cell-state transitions linked to disease severity in pediatric eosinophilic esophagitis using single-cell and bulk transcriptomic data.

This study shows that macrophage-derived CCL24 worsens fibrosis and cardiac dysfunction in heart failure by activating fibroblasts through the CCR3 receptor.

This study investigates the distinct roles of TSLP and IL-33 in experimental eosinophilic esophagitis, finding that TSLP is a key upstream regulator of IL-13 and a potential therapeutic target.

This study investigates the role of C3aR-activated mast cells in eosinophilic esophagitis, showing increased degranulation and cytokine release in EoE patients.

EGIDExpress is a web app that visualizes and shares large EGID datasets, enabling data exploration and hypothesis generation for researchers.

This study identifies epigenetic and transcriptional dysregulation in CD4+ T cells of atopic dermatitis patients, linking genetic risk variants to altered chromatin accessibility and NFKB1 binding.

The paper uses immune cell type-specific methylation patterns in circulating cell-free DNA to monitor immune dynamics and find that immune-derived cfDNA levels reflect immune homeostasis and predict immune responses to perturbations.

The paper investigates how genetic, inflammatory, and epithelial cell differentiation factors regulate CAPN14 expression in eosinophilic esophagitis.