Jonathan Josephs‐Spaulding

This paper identifies a metabolic vulnerability in leptomeningeal ALL cells due to thiol scarcity in CSF, making them susceptible to ferroptosis through disruption of selenocysteine biosynthesis and GPX4 activity.

This study shows Drosophila and their gut bacteria exchange pantothenate for nitrogen, reprogramming fly metabolism and supporting bacterial growth.

This paper uses metatranscriptomics and metabolic modeling to analyze patient-specific urinary microbiomes during infection, identifying metabolic dependencies and potential interventions for antibiotic-resistant UTIs.

This paper uses transcriptomics and machine learning to reconstruct the transcriptional regulatory network of L. reuteri, identifying key regulatory signals and metabolic pathways.