Bernardo Lessa Horta

This study evaluates how imputation reference panel composition affects imputation quality in four Latin American cohorts, finding that increasing Latin American representation improves quality but results vary by population and chromosome.

This study presents a high-coverage whole-genome sequencing dataset of 1,171 admixed elderly Brazilians, identifying novel variants and demonstrating the utility of WGS for genomic and clinical research in underrepresented populations.

The paper identifies a West African-associated regulatory variant with a strong female-specific effect on BMI and fat mass in Brazilian admixed populations.

The paper analyzes African genetic contributions to the Americas, showing regional ancestry patterns and admixture dynamics linked to historical factors.

This study analyzes the genetic impact of European colonization on the Americas using genome-wide data from 12,000 individuals, revealing complex contributions from European, African, and other sources.

The paper analyzes genetic variants at the PCSK9 locus to assess their phenotypic effects on lipid levels and disease outcomes, finding concordance with PCSK9 inhibitor trials for myocardial infarction but discordance for type 2 diabetes.

This study identifies over 50 new genetic loci associated with pulmonary function through a multiethnic meta-analysis of 90,715 individuals.