Hua Huang

Expanding the HIF-2α proteomic interactome with TurboID proximity labeling.

This study expands the HIF-2α proteomic interactome using TurboID proximity labeling, identifying 329 novel interactors and linking some to poor patient survival in breast cancer.

Precision CRISPR annotation of the functional enhancer landscape in primary human T cells

The paper develops a CRISPRi platform to annotate functional enhancers in human T cells, identifying novel CREs and their regulatory roles in immune responses.

Deciphering the role of histone modifications in memory and exhausted CD8 T cells

This study identifies how histone modifications regulate gene expression in memory and exhausted CD8 T cells, revealing distinct epigenetic programs between these cell types.

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

ACSS2 contributes to transcriptional regulation in Cajal-Retzius cells in a mouse model of Alzheimer's disease

This study shows ACSS2-mediated histone acetylation is critical for learning and memory in a mouse AD model, with acetate supplementation rescuing deficits.

Histone acetylation in an Alzheimer's disease cell model promotes homeostatic amyloid-reducing pathways

The paper investigates how reducing histone acetylation in Alzheimer's disease models affects amyloid-reducing pathways and amyloid-beta secretion.