Author

Jennifer E. Wu

Parker Institute for Cancer ImmunotherapyORCID 0000-0002-9302-8904Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Amy E. BaxteriD· 2 shared Divij MathewiD· 2 shared E. John WherryiD· 2 shared Josephine Ruth GilesiD· 2 shared Max KlapholziD· 2 shared Sasikanth ManneiD· 2 shared Shin Foong NgiowiD· 2 shared Víctor AlcaldeiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Amy E. BaxterORCID

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2 papers

Recent·Most cited

PD-1 blockade drug holiday improves exhausted progenitor CD8 T cell (Tpex) reinvigoration by avoiding Tpex adaptive resistance

Shin Foong Ngiow, Ryan P. O’Connell, Sasikanth Manne, Yinghui Jane Huang, Josephine Ruth Giles, Víctor Alcalde, Divij Mathew, Max Klapholz, Kito Nzingha, Zeyu Chen, Amy E. Baxter, Kunal P. Patel, Jennifer E. Wu, Ryan P. Staupe, Mohammed-Alkhatim A. Ali, , E. John Wherry

The paper shows that a drug holiday during PD-1 blockade improves reinvigoration of exhausted T cells by restoring progenitor cell function and reducing adaptive resistance.

bioRxiv · May 18, 2026 · PreprintImmunology

Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8+ T cells underlies distinct functional potential

Simone L. Park, Mark M. Painter, Sasikanth Manne, Víctor Alcalde, Maura McLaughlin, Matthew A. Sullivan, Divij Mathew, Leonel Torres, Yinghui Huang, David B. Reeg, Naomi R. Douek, Trenton Campos, Max Klapholz, Maria Andrea Cardenas, Victoria Fang, , E. John Wherry

The paper identifies TR-TEX cells as distinct from TRM cells, showing they have unique transcriptional regulation and respond differently to PD-1 inhibition.

bioRxiv · Aug 8, 2025 · PreprintImmunology